IVF treatment is an emotional, physical and financial roller coaster ride. Only 40-50 % of those who undergo IVF treatment will end up having a baby. For the rest, the question of why the failure happened inevitably comes up. As with most biological events, human reproduction is a very complex process and even today there are many things science does not know.
The main reasons for IVF failure can be
QUALITY OF THE EMBRYO
Most often a failed IVF cycle stems from issues with the embryo. Many embryos are not able to implant after transfer to the uterus because they are flawed in some way or there could be chromosomal issues. Even embryos that look good in the lab may have defects that cause them to die instead of growing. In most cases, it’s not that your uterus has something wrong with it so you can’t carry a baby. The embryo does not implant because it is not healthy enough to grow.
AGE OF THE EGGS
As women grow older the quality and quantity of a woman’s eggs begin to worsen. This will greatly affect her chances of success with IVF as well. Older women who use donor eggs have success rates nearly the same as those of younger women. Egg quality is all-important to have healthy embryos and younger eggs usually have better quality.
Women might have a poor ovarian response to stimulation resulting in fewer eggs or poor quality eggs. This may be more likely if there is
- low AMH
- high FSH levels
- Age over 37 years
An unsuccessful IVF cycle may also occur if the embryo is unable to properly attach to the uterine lining. This can occur with a non-viable embryo or due to issues of the uterus. Thin endometrium (lining of the womb) may lead to a lower implantation rate. Abnormalities within uterus such as polyps or fibroids, uterine septum, adenomyosis etc. can cause problems. Immunologic dysfunction can also lead to implantation failure.
PROBLEMS WITH EMBRYO TRANSFER
Embryo transfer is one of the most important steps of the entire cycle. The embryos must be placed in the correct location and trial embryo transfer is done in order to determine in advance the optimal location for embryo placement.
Abnormal sperm appears to be a less common factor affecting the success of an IVF cycle but it still plays a role.
If you have previously undergone IVF treatment and have been unsuccessful we may be able to help.
Do you want to know What if IVF fails?
To know about it you can read this blog: What if IVF fails?